Ambien (Zolpidem) is a drug primarily used for the short-term treatment of sleep problems. The guidelines recommend using it only after trying the tips and behavioral changes. It reduces sleep time by about 15 minutes and helps patients stay asleep longer in larger doses. It is taken orally and is available in conventional tablets or sublingual tablets and oral spray.
Indications and dosage
AMBIEN (zolpidem tartrate) is indicated for the short-term treatment of insomnia characterized by difficulty in initiating sleep. AMBIEN has been shown to reduce sleep latency up to 35 days in controlled clinical studies.
Clinical trials in support of efficacy lasted 4 to 5 weeks and final formal assessments of sleep latency were made at the end of treatment.
Dosage for adults
Use the lowest effective dose for the patient. The recommended starting dose is 5 mg for women and 5 or 10 mg for men, to be taken once a night immediately before bedtime, and there is at least 7 to 8 hours left before the scheduled waking time. If the 5 mg dose is not effective, the dose may be increased to 10 mg. In some patients, high morning blood levels after the 10 mg dose increase the risk of impaired driving the next day and other activities requiring maximum alertness. The total dose of AMBIEN should not exceed 10 mg once daily immediately before bedtime. Ambien should be taken in a single dose and should not be re-administered during the same night.
The recommended initial doses for women and men are different because the clearance of zolpidem is lower in women.
Elderly or debilitated patients may be particularly sensitive to the effects of zolpidem tartrate. The recommended dose of AMBIEN in these patients is 5 mg once daily immediately before bedtime.
Patients with mild to moderate hepatic impairment do not clear the drug as quickly as normal subjects. The recommended dose of AMBIEN in these patients is 5 mg once daily immediately before bedtime. Avoid using AMBIEN in patients with severe hepatic impairment as this may contribute to encephalopathy.
Use with CNS depressants
Dosage adjustment may be necessary when AMBIEN is combined with other CNS depressant drugs because of its potentially additive effects.
The effect of AMBIEN may be slowed by ingestion with or immediately after a meal.
Dosage Forms and Strengths
AMBIEN is available in 5 mg and 10 mg tablets for oral administration. The tablets are not marked.
AMBIEN 5 mg tablets are capsule-shaped, pink, film-coated, with an AMB inscription 5 engraved on one side and 5401 on the other.
AMBIEN 10 mg tablets are in capsule form, white, film-coated, with an inscription engraved AMB 10 on one side and 5421 on the other.
Storage And Handling
AMBIEN 5 mg tablets are capsule-shaped, pink, film-coated, with the imprint AMB 5 engraved on one side and 5401 on the other, and are in the form of: